In Preparation/Under Review
| Gomez, A.E., Alvarado, K., Yase, R. A., Hsu, Y-H., Hulleman, J.D., and Kwon, R.Y. (2024) Dominant nonsense mutations in efemp1 alter vertebral and craniofacial characteristics in adult zebrafish. Published as a preprint |
2024
| Mendoza, M.M., Poole, K., DiCesare, S.M., Nakahara, E., Bhatt, M.P., Hulleman, J.D., and Petroll, W.M. (2024) The role of vimentin in human corneal fibroblast spreading and myofibroblast transformation. |
| Daniel, S., and Hulleman, J.D. Ω . Exploring ocular fibulin-3 (EFEMP1): anatomical, age-related, and species perspectives. [In Press, BBA: Molecular Basis of Disease.] ( Ω - corresponding author) PMID: 38750770 |
| DiCesare, S.M., Ortega, A.J., Collier, G.E., Daniel, S., Thompson, K.N., McCoy, M.K., Posner, B.A., and Hulleman, J.D. Ω GSK3 inhibition reduces ECM protein production and prevents pathology associated with an early onset form of age-related macular degeneration. [In Press, Journal of Clinical Investigation - Insight. Published as a preprint] ( Ω - corresponding author) |
| Daniel, S., Ortega, A.J., and Hulleman, J.D. Ω RPE basal lamina biology and pathophysiology relevant to age- related macular degeneration. Advances in Experimental Medicine and Biology. [In Press] ( Ω - corresponding author) |
| Lankford, K.P., and Hulleman, J.D. Ω Protocol for HiBiT tagging endogenous proteins using CRISPR/Cas9 gene editing. STAR Protocols. 5(2):103000 ( Ω - corresponding author). PMID: 38598333 |
| Zegeye, Y., Aredo, B., Yuksel, S., He, Y-G., Tang, M., Li, X., DiCesare, S.M., Hulleman, J.D., Gautron, L., Ludwig, S., Moresco, E.M., Beutler, B.A., Ufret-Vincenty, R.L. (2024) Deficiency of Herc3, an E3 ubiquitin ligase, leads to accumulation of subretinal microglia and retinal degeneration. Scientific Reports. 14(1):3010 PMID: 38321224 |
2023
| Hayes, M.H., Woodard, D.R., and Hulleman, J.D. Ω. Ocular amyloid, condensates, and aggregates – higher-order protein assemblies participate in both retinal degeneration and function. Advances in Experimental Medicine and Biology. 1415: 263-267 PMID: 37440043 |
| Yuksel, S., Aredo, B., Zegeye, Y., Zhao, C., Tang, M., Li, X., Hulleman, J.D., Gautron, L., Ludwig, S., Moresco, E.M., Butovich, I.A., Beutler, B.A., and Ufret-Vincenty, R.L. (2023). Forward genetic screening using fundus spot scale identifies an essential role for Lipe in retinal homeostasis. Communications Biology. 6(533) PMID: 37198396 |
2022
| Burdon, K.P., Graham, P., Hadler, J., Hulleman, J.D., Prasutto, F., Boese, E.A., Craig, J.E., Fingert, J., Hewitt, A.W., J.D. Hulleman 4 Siggs, O.M., Whisenhunt, K., Young, T.L., Mackey, D.A., Dubowsky, A., and Souzeau, E. (2022). Specifications of the ACMG/AMP variant curation guidelines for MYOC: recommendations from the ClinGen Glaucoma Expert Panel. Human Mutation. 43(12):2170-2186. Selected as an Editor’s Choice article. PMID: 36217948 |
| Nakahara, E., Mullapudi, V., Collier, G.E., Joachimiak, L.A., and Hulleman, J.D. Ω. A new DHFR-based destabilizing domain with enhanced turnover and broader flexibility. ACS Chemical Biology. 17(10):2877-2889 ( Ω - corresponding author). PMID: 36122928 |
| Woodard, D.R., Daniel, S., Nakahara, E., Abbas, A., DiCesare, S.M., Collier, G.E., and Hulleman, J.D. Ω. A loss-of- function cysteine mutant in fibulin-3 (EFEMP1) forms aberrant extracellular disulfide-linked homodimers and alters extracellular matrix composition. Human Mutation. 43(12):1945-1955 ( Ω - corresponding author). Selected as an Editor’s Choice article. PMID: 35998264 |
| Peng, H.*, Ramadurgum, P.*, Woodard, D.R.*, Daniel, S., Renwick, M., Nakahara, E., Datta, S., Chen, B., Aredo, B., Ufret-Vincenty, R.L. and Hulleman, J.D. Ω. Utility of the DHFR-based destabilizing domain across mouse models of retinal degeneration. iScience. 25(5):104206 (*- equal contribution, Ω - corresponding author). PMID: 35521529 |
| Nakahara, E., and Hulleman, J.D. Ω. A simple secretion assay for assessing new and existing myocilin variants. Current Eye Research. Mar. 25; 1-5 ( Ω - corresponding author). PMID: 35196929 |
2021
| Manna, M.S., Tamer, Y.T., Gaszek, I., Poulides, N., Ahmed, A., Wang, X., Toprak, F.C.R., Woodard, D.R., Koh, A.Y., Williams, N., Borek, D., Atilgan, A.R., Hulleman, J.D., Atilgan, C., Tambar, U.K., and Toprak, E. A trimethoprim derivative impedes antibiotic resistance evolution. Nature Communications. 12(1): 2949. Featured Article in Nat. Comm. PMID: 34011959 |
| Woodard, D.R., Xing, C., Ganne, P., Liang, H., Mahindrakar, A., Sankurathri, C., Hulleman, J.D. # , and Mootha, V.V. # A novel homozygous P388S mutation in TULP1 causes protein instability and retinitis pigmentosa. Molecular Vision 27: 179-190 ( # - co-corresponding author) PMID: 33907372 |
| Woodard, D.R., Nakahara, E., and Hulleman, J.D. Ω. Clinically-identified C-terminal mutations in fibulin-3 are prone to misfolding and destabilization. Scientific Reports. 11(1): 2998. ( Ω -corresponding author) PMID: 33542268 |
2020
| Daniel, S., Renwick, M., Datta, S., Chau, V.Q., Zode, G.S., Wade, E.M., Robertson, S.P., Petroll, W.M., and Hulleman, J.D. Ω Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity. Journal of Molecular Medicine, 98(11): 1639-1656 ( Ω -corresponding author) PMID: 32964303 |
| Ramadurgum, P., Daniel, S., and Hulleman, J.D. Ω Protocol for in vivo evaluation and use of destabilizing domains in the eye, liver and beyond. Invited article. STAR Protocols, 1(2): 100094 ( Ω -corresponding author) PMID: 32995756 |
| Rong, Z., Gong, X., Hulleman, J.D., Corey, D.R., and Mootha, V.V. (2020) Trinucleotide repeat-targeting dCas9 as a therapeutic strategy for Fuchs’ endothelial corneal dystrophy. Translation Vision Science and Technology, 9(9): 47 PMID: 32934897 |
| Landeck, N., Strathearn, K.E., Ysselstein, D., Buck, K., Dutta, S., Banerjee, S., Lu, Z., Hulleman, J.D., Hindupur, J., Lin, L-K., Padalkar, S., McCabe, G.P., Stanciu, L.A., Lyubchenko, Y.L., Kirik, D., and Rochet, J-C. (2020) Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein. Molecular Neurodegeneration, 15(1): 49. PMID: 32900375 |
| Ramadurgum, P., and Hulleman, J.D. Ω Protocol for designing small molecule-regulated destabilizing domains for in vitro use. Invited article. STAR Protocols, 1(2): 100069 ( Ω -corresponding author) PMID: 32995752 |
| Zhou, M., Weber, S.R., Zhao, Y., Chen, H., Barber, A., Grillo, S.L., Wilis, C.A., Wang, H.G., Hulleman, J.D., and Sundstrom, J.M. (2020) Expression of R345W-Fibulin-3 induces epithelial-mesenchymal transition in retinal pigment epithelial cells. Frontiers in Cell and Developmental Biology, 8: 469 PMID: 32637411 |
| Ramadurgum, P., Woodard, D.R., Daniel, S.N., Peng, H., Mallipeddi, P.L., Niederstrasser, H., Mihelakis, M., Chau, V.Q., Douglas, P.M., Posner, B.A., and Hulleman, J.D. Ω. Simultaneous control of endogenous and user-defined genetic pathways using new ecDHFR pharmacological chaperones. Cell Chemical Biology, 27(5): 622-634. ( Ω - corresponding author). PMID: 32330442 |
| Chau, V.Q., Hu, J., Gong, X., Hulleman, J.D., Ufret-Vincenty, R.L., Rigo, F., Prakash, T.P., Corey, D., and Mootha, V.V. Delivery of antisense oligonucleotides to the corneal endothelium. Nucleic Acid Therapeutics, 30(4): 207-214. Featured Article in Nuc. Acid Ther. PMID: 32202944 |
2019
| Datta, S., Peng, H., and Hulleman, J.D. Ω. Small molecule-based inducible gene therapies for retinal degeneration. Advances in Experimental Medicine and Biology, 1185: 65-69. ( Ω - corresponding author) PMID: 31884590 |
| Peng, H.*, Chau, V.Q.*, Phetsang, W., Sebastian, R.L., Stone, M.R.L., Datta, S., Renwick, M., Tamer, Y.T., Toprak, E., Koh, A.Y., Blaskovich, M.A.T. and Hulleman, J.D. Ω. Non-antibiotic small-molecule regulation of DHFR-based destabilizing domains in vivo. Molecular Therapy – Methods and Clinical Development, 15: 27-39. (* - equal contribution, Ω - corresponding author) PMID: 31649953 |
| Peng, H., and Hulleman, J.D. Ω. Prospective application of activity-based protein profiling in eye research – Insights into ocular protease biology and pathology. Invited review. International Journal of Molecular Science, 20(16): 3855. ( Ω - corresponding author) PMID: 31398819 |
2018
| Datta, S., Renwick, M., Chau, V.Q., Zhang, F., Nettesheim, E., Lipinski, D.M., and Hulleman, J.D. Ω. A destabilizing domain allows for fast, non-invasive, conditional control of protein abundance in the mouse eye – Implications for ocular gene therapy*. 58(12): 4909-4920. Investigative Ophthalmology and Vision Science. ( Ω - corresponding author) *article chosen as a Featured Article, included in the Hot Topic 2017 Collection in IOVS and top 5 viewed paper of 2018 (Silverchair analytics). PMID: 30347085 |
| Bamberger, C., MartínezBartolomé, S., Montgomery, M., Pankow, S. Hulleman, J.D., Kelly, J.W., and Yates, J.R. Deducing missing proteins and proteoforms in quantitative proteomics. Nature Communications, 9(1): 2320 PMID: 29899466 |
| Wong, M.Y., Doan, N.D., DiChiara, Papa, L., A.S., Cheah, J.H., Soule, C.K., Watson, N., Hulleman, J.D., and Shoulders, M.D. A high-throughput assay for collagen secretion suggests an unanticipated role for Hsp90 in collagen production. Biochemistry, 57(19): 2814-2827. PMID: 29676157 |
2017
| Vu, K.T., Zhang, F., and Hulleman, J.D. Ω Conditional, genetically-encoded, small molecule-regulated inhibition of NFB signaling in RPE cells*. Investigative Ophthalmology and Vision Science, 58(10): 4126-4137 ( Ω - corresponding author). *article chosen as a Featured Article, Most Viewed and an Editor’s Top Pick. PMID: 28829844 |
| Vu, K.T., and Hulleman, J.D. Ω An inducible form of Nrf2 confers enhanced protection against acute oxidative stresses in RPE cells. Experimental Eye Research, 164: 31-36 ( Ω - corresponding author). PMID: 28782506 |
2016
| Hulleman, J.D. *Ω , Genereux, J.C. * , and Nguyen, A. Mapping wild-type and R345W fibulin-3 intracellular interactomes. Experimental Eye Research, 153: 165-169 (* - equal contribution, Ω - corresponding author). PMID: 27777122 |
| Zadoo, S., Nguyen, A., Zode, G., and Hulleman, J.D. Ω A novel luciferase assay for sensitively monitoring myocilin variants in cell culture. Investigative Ophthalmology and Vision Science 57(4): 1939-1950 ( Ω - corresponding author). PMID: 27092720 |
| Nguyen, A. and Hulleman, J.D. Ω Evidence of alternative cystatin c signal sequence cleavage which is influenced by the A25T polymorphism. PLoS One. 11(2) ( Ω - corresponding author). PMID: 26845025 |
| Hulleman, J.D., Nguyen, A., Ramprasad, V.L., Murugan, S., Gupta, R., Mahindrakar, A., Angara, R., Sankurathri, C., and Mootha, V.V. (2016) A novel H395R mutation in MKKS/BBS6 causes retinitis pigmentosa and polydactyly without other findings of Bardet-Biedl or McKusick-Kaufman syndrome. Molecular Vision, 22: 73-81. PMID: 26900326 |
| Hulleman, J.D. Ω Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to age-related macular degeneration and potential therapies. Advances in Experimental Medicine and Biology, 854: 153-158. ( Ω - corresponding author). PMID: 26427406 |
2015
| Nguyen, A. and Hulleman, J.D. Ω Differential tolerance of ‘pseudo-pathogenic’ tryptophan residues in calcium- binding EGF domains of short fibulin proteins. Experimental Eye Research, 130: 66-72. ( Ω - corresponding author). PMID: 25481286 |
| Hulleman, J.D. # and Kelly, J.W. # (2015) Genetic ablation of N-linked glycosylation reveals two important folding pathways for mutant fibulin-3, a protein associated with retinal degeneration. FASEB Journal, 29(2): 565-75 ( # - co- corresponding author). PMID: 25389134 |
2014
| Chen, J.J., Genereux, J.G., Qu, S., Hulleman, J.D., Shoulders, M.D., and Wiseman, R.L. Increasing ER quality control stringency through ATF6 activation reduces the secretion and extracellular aggregation of destabilized variants of an amyloidogenic protein. Chemistry and Biology 21(11): 1–11. PMID: 25444553 |
| Cooley, C.B., Ryno, L.M., Plate, L., Morgan, G.J., Hulleman, J.D., Kelly, J.W., and Wiseman, R.L. Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain. Proceedings of the National Academy of Science, U.S.A. 111(36): 13046-13051. PMID: 25157167 |
| Wang, X., Cattaneo, F., Ryno, L.M., Hulleman, J.D., Reixach, N., and Buxbaum, J.N. (2014) The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice. Journal of Neuroscience, 34(21): 7253-65. PMID: 24849358 |
2013
| Hulleman, J.D. # , Brown, S.J., Rosen, H., and Kelly, J.W. # A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion. Journal of Biomolecular Screening, 18(6): 647-658 ( # - co- corresponding author). PMID: 23230284 |
2012
| Hulleman, J.D. # , Balch, W.E., and Kelly, J.W. # Translational attenuation differentially alters the fate of disease- associated fibulin proteins. FASEB Journal, 26 (11): 4548-4560 ( # - co-corresponding author). PMID: 22872678 |
| Madian, A.G., Hindupur, J., Hulleman, J.D., Diaz-Maldonado, N., Guigard, E., Kay, C.M., Rochet, J-C., and Regnier, F.E. Effect of single amino acid substitution on oxidative modifications of the Parkinson’s disease-related protein, DJ-1. Molecular & Cellular Proteomics, 11 (2): M111.010892. PMID: 22104028 |
2011
| Hulleman, J.D.# , Kaushal, S., Balch, W.E., and Kelly, J.W. # Compromised mutant EFEMP1 secretion remedied by proteostasis network alteration. Molecular Biology of the Cell, 22 (24): 4765-4775 ( # - co-corresponding author). PMID: 22031286 |
2009
| Usui, K.*, Hulleman, J.D.*, Paulsson, J.F., Siegel, S.S., Powers, E.T., and Kelly, J.W. Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity. Proceedings of the National Academy of Science, U.S.A., 106 (44): 18563-18568 (* - equal contribution). PMID: 19841277 |
| Padalkar, S., Hulleman, J.D., Kim, S.M., Tumkur, T., Rochet, J-C., Stach, E., and Stanciu, L.A. Fabrication of ZnS nanoparticle chains on a protein template. Journal of Nanoparticle Research (doi: 10.1007/s11051-009-9689-8 ). PMID: 21804765 |
| Rochet, J-C. and Hulleman, J.D. α-Synuclein self-assembly in Parkinson’s disease: insights from biophysical analyses. In T.F. Outeiro (Ed.), Protein Misfolding in Biology and Disease. Trivandrum, India: Research Signpost. |
2008
| Liu, F., Nguyen, J.L., Hulleman, J.D., Li, L., Rochet, J-C. Neuroprotective function of DJ-1 and MsrA in a cellular model of Parkinson’s disease. Journal of Neurochemistry, 105 (6): 2435-2453. PMID: 18331584 |
| Padalkar, S., Hulleman, J.D., Rochet, J-C., Stach, E., Stanciu, L. Protein-templated semiconductor nanoparticle chains. Nanotechnology, 19 (27) (doi: 10.1088/0957-4484/19/27/275602 ). PMID: 21828709 |
| Colby, R., Hulleman, J.D., Padalkar, S., Rochet, J-C., Stanciu, L. Biotemplated synthesis of metallic nanoparticle chains on an α-synuclein fiber scaffold. Journal of Nanoscience and Nanotechnology, 8 (2): 973–978. PMID: 18464436 |
2007
| Zakharov, S., Hulleman, J.D., Dutseva, E., Antonenko, Y., Rochet, J-C., Cramer, W.A. (2007) Helical α-synuclein forms highly conductive ion channels. Biochemistry, 46 (50): 14369-14379. PMID: 18031063 |
| Hulleman, J.D., Mirzaei, H., Guigard, E., Taylor, K.L., Ray, S.S., Kay, C.M., Regnier, F.E., Rochet, J-C. Destabilization of DJ-1 by a familial substitution and oxidative modifications: implications for Parkinson’s disease. Biochemistry, 46 (19): 5776-5789. PMID: 17451229 |
| Padalkar, S., Hulleman, J.D., Colby, R., Cunzeman, K., Rochet, J-C., Stach, E., Stanciu, L. (2007) α-synuclein as a template for the synthesis of metallic nanowires. Nanotechnology, 18 (5) (doi: 10.1088/0957- 4484/18/5/055609 ). |
