Honored to have been selected to receive an Alcon Research Institute (ARI) Senior Researcher Grant to develop our next-generation retinal diagnostic platform. Looking to hire a #postdoc to work on this exciting project. Candidates with strong experience in retinal imaging, #NGS, and/or #CRISPR, please reach out! #hiring #ophthalmology #AMD
Happy to share the latest from our lab on new fibulin-3 (EFEMP1) mutations that cause disruptions to disulfide bonding and trigger ER stress. Many of these human mutations are likely associated with sub-clinical connective tissue disorders and provide additional insight into the nuances of fibulin-3 folding and secretion related to human disease. Congrats to Anna Roovers on her first co-author publication! #ECM #ProteinMisfolding
In our recent ACS Chemical Biology publication, we developed new #HiBiT-tagging approaches for #AMD-associated proteins (e.g., high temperature-requirement A1 [HTRA1], performed high-throughput screening, and identified Chicago Sky Blue (CSB, an azo [R-N=N-R']-based molecule) as a significant enhancer of HTRA1 abundance. Azo compounds are commonly used as pigments, but can also have surprising biological functions (anti-bacterial, anti-amyloid, etc.). Molecules such as CSB may serve as tool compounds or leads in developing new therapies to combat the decline in HTRA1 levels observed in individuals harboring select AMD risk SNPs. Read here. #PromegaCorporation #Ophthalmology #VisionResearch ACS Publications
Congratulations to OVNS colleague Harald Junge and his team on their #ScienceSignaling paper unlocking a new role for #p53 regulation in #retinal vascular biology. #NEIfunded #UMNproud
